Indian Journal of Health Sciences and Biomedical Research KLEU

REVIEW ARTICLE
Year
: 2022  |  Volume : 15  |  Issue : 2  |  Page : 114--120

Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis


Animesh Chowdhury1, Manoj Lama2 
1 Department of Zoology, University of Gour Banga; Department of Zoology, Malda College, Malda, West Bengal, India
2 Department of Zoology, University of Gour Banga, Malda, West Bengal, India

Correspondence Address:
Dr Manoj Lama
Molecular Immunology Laboratory, Department of Zoology, University of Gour Banga, Malda - 732 103, West Bengal
India

This meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial. The association studies related to HLA-G gene polymorphisms and RA were extracted from PubMed, Mendeley, ScienceDirect, and Google Scholar databases up to December 31, 2020. Finally, a total of 1516 cases and 1683 control samples were chosen from 7 published research articles for this meta-analysis. A significant association was evaluated using the pooled odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant, recessive, and additive models. Overall, there is absence of significant association between 14-bp ins/del polymorphism and RA (recessive model: OR = 1.012, 95% CI = 0.841–1.217, P = 0.900; dominant model: OR = 1.068, 95% CI = 0.919–1.241, P = 0.393; ins/ins vs. del/del: OR = 1.059, 95% CI = 0.861–1.303, P = 0.587). In the case of +3142G>C polymorphism, the recessive model (OR = 1.332, 95% CI = 1.083–1.640, P = 0.007) showed a significant association with RA susceptibility. When subgroup analysis was done by ethnicity, +3142G>C polymorphism was found to be significantly associated with RA susceptibility in the Asian population under the recessive model (OR = 1.450, 95% CI = 1.048–2.006, P = 0.025). This meta-analysis brings to light that there was no significant association between 14-bp ins/del polymorphism and RA susceptibility. Whereas, +3142G>C polymorphism was found to be significantly associated with susceptibility to RA.


How to cite this article:
Chowdhury A, Lama M. Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis.Indian J Health Sci Biomed Res 2022;15:114-120


How to cite this URL:
Chowdhury A, Lama M. Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis. Indian J Health Sci Biomed Res [serial online] 2022 [cited 2022 Jun 27 ];15:114-120
Available from: https://www.ijournalhs.org/article.asp?issn=2542-6214;year=2022;volume=15;issue=2;spage=114;epage=120;aulast=Chowdhury;type=0