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Cover page of the Journal of Health Sciences
Year : 2022  |  Volume : 15  |  Issue : 2  |  Page : 176-179

Primary neuroendocrine breast carcinoma: A rare case report

1 Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Surgical Oncology, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Madhu Kumar
Department of Pathology, King George's Medical University, Shahmina Road, Chowk, Lucknow - 226 003, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/kleuhsj.kleuhsj_389_21

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Primary neuroendocrine carcinoma of the breast is a very rare occurrence accounting for <0.1% of all breast cancers. For the diagnosis, it requires the diffuse expression of neuroendocrine markers (chromogranin, synaptophysin, neuron-specific enolase) and the lack of simultaneous neuroendocrine carcinoma in extramammary sites. The breast carcinomas with focal neuroendocrine differentiation are defined as scattered tumor cells that stain positive with neuroendocrine markers. These tumors are usually seen in elderly women around sixth or seventh decade of life, as reported in literatures. The high nuclear grade and regional lymph node metastasis was also significant negative prognostic factors for overall survival. We study a case of primary neuroendocrine carcinoma of breast in a 46-year-old lady, on the basis of histopathology and immunohistochemistry.

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