Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 167
  • Home
  • Print this page
  • Email this page
Cover page of the Journal of Health Sciences
Year : 2017  |  Volume : 10  |  Issue : 2  |  Page : 155-159

“Comparative evaluation of intranasal dexmedetomidine and intranasal midazolam for premedication in children undergoing anesthesia”: A 1-year double-blind randomized controlled trial

Department of Anesthesiology, KLE'S Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka, India

Correspondence Address:
Narendra Malineni
Department of Anesthesiology, KLE'S Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi - 590 010, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2349-5006.207264

Rights and Permissions

Introduction: Children undergoing surgical procedures can experience significant anxiety and distress during perioperative period. Use of sedative premedication helps to reduce anxiety and facilitate a smooth induction of anesthesia. Midazolam is the most commonly used premedication agent with adverse effects such as behavioral changes, hiccups, and paradoxical hyperactive reactions. Dexmedetomidine, a highly selective α-2 agonist, has sedative properties. Aims and Objectives: The aim and objective of this study was to compare the efficacy of intranasal dexmedetomidine and intranasal midazolam for premedication in pediatric age group for parental separation anxiety and acceptance of anesthesia mask. Materials and Methods: This study included 60 American Society of Anesthesiologists I–II patients aged 1–10 years undergoing lower abdominal and lower limb surgeries under caudal epidural anesthesia. Ethical committee's clearance and informed consent were obtained. Patients were allocated into two groups by a computer-generated randomization table to receive 0.2 mg/kg intranasal midazolam in Group M and 1 μg/kg dexmedetomidine in Group D intranasally using 1 ml tuberculin syringe. The Parental Separation Anxiety Scale (PSAS) and Mask Acceptance Scale (MAS) were assessed by an anesthesiologist blinded to the drug given. Heart rate and oxygen saturation were monitored till the end of the procedure. Results: Demographic data were comparable in both groups (P > 0.05). Mean PSAS was 1.2 ± 0.40 in dexmedetomidine group and 1.6 ± 0.56 in midazolam group (P = 0.003). Mean mask acceptance score (MAS) at the time of induction was 1.7 ± 0.59 in dexmedetomidine group and 2.1 ± 0.58 in midazolam group (P = 0.02). Conclusion: Intranasal dexmedetomidine 1 μg/kg is an effective alternative for premedication in children undergoing anesthesia and it results in better parent separation and better mask acceptance at the time of induction when compared to intranasal midazolam 0.2 mg/kg without much side effects or complications.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded166    
    Comments [Add]    

Recommend this journal